Synthesis, transformation and preliminary bioassay of 3-(thiazol-2-yl(p-tolyl)amino)propanoic acid derivatives


 1,3-Thiazole is one of the most attractive cores in heterocycles chemistry and drug discovery. Its widespread use diverse medicinal substances makes thiazole a versatile scaffold, which leads to novel generation efficient pharmaceuticals. This study was intended synthesize series N,N-disubstituted aminothiazole derivatives having various fragments at 4th 5th positions ring. The formation such carried out via Hantsch reaction, condensation reactions with aldehydes, bromination chalcone-type derivatives. Another goal this investigate antibacterial properties obtained compounds against some gram-positive Bacillus species as B. coagulans, subtilis megaterium gram-negative Escherichia coli. As it shown by our studies recent years, synthesized thiazoles can serve for future development potent targets.